The Australian exclusive match will take place on 18 July and marks the first London Derby to be played in Australia between the Premier League opponents.
West Ham will also take on home heroes Perth Glory at Optus Stadium 15 July.
The blockbuster games will be played at highly awarded Optus Stadium, which has been voted Australia's best stadium for a third year in a row.
Both EPL matches are expected to attract interstate and international visitors, support local hospitality and tourism businesses and see millions of dollars generated for the WA economy.
The must-see matches occur just before the FIFA Women's World Cup 2023 descends on Perth, with 5 matches to be held between 22 July and 3 August at Perth Rectangular Stadium.
Perth will host 7 major football matches involving international teams in just 20 days.
Last year, 4 EPL teams — Manchester United, Aston Villa, Leeds United and Crystal Palace — played at Optus Stadium, generating an economic impact of $77 million, including 4700 out-of-State visitors to Perth.
Tottenham Hotspur, who are currently in fourth position in the EPL, and West Ham are 2 of the world's best known football clubs, both with a rich history and tradition.
Tickets to the matches go on sale next week, with club presales beginning on 24 March to allow international fans and Australian members to get their hands on tickets first.
Tickets on sale on from 28 March
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